Urine lipoarabinomannan as initial markers for active pulmonary tuberculosis

Abdelrahman Elsawy, Elrashdy M. Redwan

Research output: Contribution to journalJournal articlepeer-review

2 Scopus citations

Abstract

The reemergence of tuberculosis as an important public health issue and the spread of drugresistant tuberculosis have emphasized the need for rapid diagnosis. However, the standard culture methods currently in use are quite slow. Lipoarabinomannan (LAM) is part of the Mycobacterium tuberculosis (TB) cell wall. It is released when bacteria are multiplying or dying. LAM can be detected in the urine since it is filtered from the blood in the kidneys. Urinary LAM detection is a promising approach for rapid diagnosis of active tuberculosis; in microbiologically confirmed TB patients, quantitative LAM detection results increased progressively with bacillary burden and immunosuppression. The current study was to evaluate the accuracy of the urine LAM test for the diagnosis of active pulmonary TB. Seventy two suspected TB cases were enrolled and subjected to smear microscopy, sputum mycobacterial culture and urine LAM testing using the Clearview TB ELISA kit. Fifty two patients (72.2%) had confirmed TB 42 with positive AFB smears and cultures for M. tuberculosis, and 10 (13.9%) with positive cultures but negative AFB smears. Among 52 confirmed TB cases, the LAM test was more sensitive than sputum smear microscopy "the sensitivity of LAM and sputum smear were 94.3% and 80.8% respectively".

Original languageEnglish
Pages (from-to)751-755
Number of pages5
JournalAustralian Journal of Basic and Applied Sciences
Volume6
Issue number3
StatePublished - Mar 2012

Keywords

  • Diagnosis
  • Human urine
  • Lipoarabinomannan
  • M. tuberculosis

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