Synthesis and reactions of some new benzo[a]phenothiazine-3,4-dione derivatives

A. H. Abdel-Rahman, E. M. Kandeel, M. A. Berghot, Marwa Abdel-Motaal

Research output: Contribution to journalJournal articlepeer-review

3 Scopus citations


The reaction of 2,3-dihydro-2,3-epoxy-1,4-naphthoquinone () with substituted anilines furnished the corresponding benzo[fused]heterocyclic derivatives. Furthermore, treatment of benzo[a]phenothiazine derivative with halo compounds, namely, ethyl bromoacetate, phenacyl bromide, dibromoethane, or chloroacetone afforded ether derivatives, respectively. Moreover, the reaction of with o-substituted aniline gave the corresponding benzo[a]phenothiazin-5-one derivatives and benzo[d][1,3]oxazin-4-one, respectively. Finally, the chromenone derivative was synthesized via the reaction of ester derivative with salicyaldhyde in refluxing pyridine. The newly synthesized compounds were characterized by spectroscopic measurements (IR, 1H NMR, 13C NMR, and mass spectra).

Original languageEnglish
Pages (from-to)298-303
Number of pages6
JournalJournal of Heterocyclic Chemistry
Issue number2
StatePublished - Mar 2013
Externally publishedYes


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