Synthesis and In Vitro Evaluation of Anti-Leukemic Potency of Some Novel Azo-Naphthol Dyes Conjugated with Metal Nanoparticles as Photosensitizers for Photodynamic Therapy

Mohamed Ezzat Khalifa, Elham A. Elkhawass, Masayuki Ninomiya, Kaori Tanaka, Mamoru Koketsu

Research output: Contribution to journalJournal articlepeer-review

1 Scopus citations

Abstract

Synthesis of some new mono azo organic compounds, based on 1-arylazo-2-naphthol nucleus is performed by diazo-coupling strategy of β-naphthol with different 1ry aromatic amines. Interestingly, the monoazo products undergo functionalized reactions to obtain the target azo naphthol derivatives (3–14). The synthesized dyes are conjugated with gold and/ or silver nanoparticles by electrostatic interaction. Photodynamic therapeutic efficiencies of the synthesized naphthol azo dyes and their conjugates have been evaluated against promyelocytic leukemia cell lines (HL-60) in dark and light conditions. Dye-Nanometal conjugates act as photosensitizers (PSs) exhibiting an enhancement of the optical properties as well as in photodynamic therapeutic efficiencies in variable degrees depending on dye structure.

Original languageEnglish
Pages (from-to)8609-8615
Number of pages7
JournalChemistrySelect
Volume5
Issue number28
DOIs
StatePublished - 31 Jul 2020

Keywords

  • Anti-Leukemia
  • Nanoparticles
  • Naphthol dyes
  • Photodynamic therapy
  • Photosensitizers

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