Synthesis and biological evaluation of some novel cyclic-imides as hypoglycaemic, anti-hyperlipidemic agents

Alaa A.M. Abdel-Aziz, Adel S. El-Azab, Sabry M. Attia, Abdulrahman M. Al-Obaid, Mohamed A. Al-Omar, Hussein I. El-Subbagh

Research output: Contribution to journalJournal articlepeer-review

42 Scopus citations

Abstract

Certain new halogenated cyclic-imides related to N-substituted phthalimide moiety were synthesized. Spacers of one or two carbon atom distances were inserted to connect the N-terminus of the cyclic-imide nuclei to the used heteroaryl groups to evaluate the effect of such alteration on biological activity. The synthesized compounds were subjected to hypoglycaemic and anti-hyperlipidemic evaluation. Some of the tested compounds proved to be more potent than the reference drugs glibenclamide and clofibrate. Compound 5e remarkably reduced serum glucose level by 55%; while 5c, 5e, 7d and 8e reduced total serum cholesterol by 58, 56, 54 and 53%, respectively. Those new cyclic-imides could be considered as useful template for future development to obtain more potent hypoglycaemic and anti-hyperlipidemic agents.

Original languageEnglish
Pages (from-to)4324-4329
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Volume46
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

Keywords

  • Anti-hyperlipidemic agents
  • Hypoglycaemic
  • Isoindolinediones
  • Synthesis
  • Tetrahydro-methyl-isoindolediones

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