Phenolics of Convolvulus arvensis L. and their related pharmacological activity

A. S. Awaad, N. H. Mohamed, Nabil H. El-Sayed, gamal soliman, T. J. Mabry

Research output: Contribution to journalJournal articlepeer-review

5 Scopus citations

Abstract

The aerial parts, roots and flowers of Convolvulus arvensis L. were investigated for their secondary metabolites. Eleven flavonoids were detected, namely kaempferol and its 3-O-β-D-glucoside, 7-O-β-D-glucoside, 3-O-α-L rhamnosyl, 7-O-β-D-glucoside, 3-O-rutinoside, 7-O-rutinoside, 3-O-α-L-rhamnoside and 3-O-β-D-galactorhamnoside as well as quercetin and its 3-O-α-L-rhamnoside and 3-O-rutinoside; four coumarins, namely 7-hydroxycoumarin (umbelliferone); 6,7-dihydroxycoumarin (esculetin); 6-methoxy-7-hydroxycoumarin (scopoletin) and 6-methoxycoumarin 7-O-glucoside (scopoletin 7-O-glucoside); the alkaloids tropine and its chloride salt; seventeen amino acids and eleven free sugars were also detected. The compounds were all identified through chemical and spectroscopic data including IR, UV, EI and CIMS, 1H and 13C NMR. The extracts showed moderate diuretic, tranquillizing, hypoglycemic, antihemorrhagic activity, in addition to antibacterial and antifungal effects. The extracts showed negative antiasthmatic effects and were found to be safe for liver and kidney functions; they also act to relieve intestinal and uterine pain.

Original languageEnglish
Pages (from-to)2818-2826
Number of pages9
JournalAsian Journal of Chemistry
Volume18
Issue number4
StatePublished - Oct 2006
Externally publishedYes

Keywords

  • Antimicrobial
  • Convolvulaceae
  • Convolvulus arvensis
  • Coumarins
  • Kaempferol and quercetin glycosides
  • Pharmacological activities

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