Nitrogen and sulfur co-doped graphene quantum dots/nanocellulose nanohybrid for electrochemical sensing of anti-schizophrenic drug olanzapine in pharmaceuticals and human biological fluids

Ashraf Mahmoud, Mater Mahneshi, Saad A. Alkahtani, Mohamed M. El-Wekil

Research output: Contribution to journalJournal articlepeer-review

11 Scopus citations

Abstract

A nanohybrid prepared from green source (nanocellulose, NC) and nitrogen, sulfur co-doped graphene quantum dots (N, S@GQDs) was prepared for the electrochemical detection of olanzapine (OLZ), atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. Polar groups on the surface of NC and N, S@GQDs provide more anchoring sites for adsorption of OLZ onto the electrode surface. In addition, it provides high conductivity, good mechanical strength, large surface area, and excellent electrical conductivity. The nanocomposite was characterized morphologically and electrochemically by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, powder X-ray diffraction (PXRD), X-ray photoelectron spectroscopy (XPS), energy dispersive X-ray spectroscopy (EDX), transmission electron microscope (TEM), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and square wave adsorptive stripping voltammetry (SWAdSV). Under the optimized conditions, the modified electrode has a good response in the range of 1.5–90.0 × 10−8 M with LOD of 0.5 × 10−8 M. The proposed electrode offers high sensitivity, selectivity, and reliability towards OLZ detection. The SWAdSV was used to determine OLZ in pharmaceutical tablets, human plasma and urine with good recoveries % and reasonable RSD% values.

Original languageEnglish
Pages (from-to)2030-2037
Number of pages8
JournalInternational Journal of Biological Macromolecules
Volume165
DOIs
StatePublished - 15 Dec 2020

Keywords

  • Human plasma and urine samples
  • N, S co-doped graphene quantum dots
  • Nanocellulose
  • Olanzapine
  • Selectivity

Fingerprint

Dive into the research topics of 'Nitrogen and sulfur co-doped graphene quantum dots/nanocellulose nanohybrid for electrochemical sensing of anti-schizophrenic drug olanzapine in pharmaceuticals and human biological fluids'. Together they form a unique fingerprint.

Cite this