New Antiparasitic Bis-Naphthoquinone Derivatives

Jana Jentzsch, Waleed Koko, Ibrahim S. Al Nasr, Tariq Ayub Khan, Rainer Schobert, Klaus Ersfeld, Bernhard Biersack

Research output: Contribution to journalJournal articlepeer-review

6 Scopus citations

Abstract

A series of bis-naphthoquinone derivatives prepared by condensation of aryl aldehydes with lawsone were tested for antiparasitic activities against Toxoplasma gondii and Trypanosoma brucei parasites. Monofluorophenyl derivative 1a, 3,4-difluorophenyl analog 1c and furyl compound 1l exhibited significant activity against T. gondii cells and appear to be new promising drug candidates against this parasite. The 3,4,5-trifluorophenyl derivative 1g and the isovanillyl derivative 1j displayed selective activity against Leishmania major amastigotes.

Original languageEnglish
Article numbere1900597
JournalChemistry and Biodiversity
Volume17
Issue number2
DOIs
StatePublished - 1 Feb 2020

Keywords

  • biological activity
  • fluorine
  • furan
  • lawsone
  • neglected tropical diseases
  • synthesis

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