Nano-amino acid cellulose derivatives: Eco-synthesis, characterization, and antimicrobial properties

Mohamed Hasanin, Ahmed El-Henawy, Wael H. Eisa, Housni El-Saied, Manal Sameeh

Research output: Contribution to journalJournal articlepeer-review

28 Scopus citations


Nowadays the using of eco-systems to synthesize new materials is the promising issue. In this work, new eco-synthesis method was developed to prepare antimicrobial cellulosic-amino acid base ligand and complexes with copper. The complex was characterized via different instrumental analysis (Fourier transform infrared spectroscopy (FTIR), UV–vis, differential scanning calorimetry (DSC), dynamic light scattering (DLS), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX)) as well as two antimicrobial screening tools (minimal inhibition concentration (MIC) and time required for killing). The UV–vis spectroscopic data indicates the metal to-ligand charge transfer transitions which is consistent with square planar geometry. DLS and SEM approved that the complex particles are in nano-size. Prepared complex appeared highly antimicrobial activity against all tested microbial organisms which can be described as broad spectrum antimicrobial agent. Rapid killing kinetics was beneficial in helping to resolve an infection more rapidly.

Original languageEnglish
Pages (from-to)963-969
Number of pages7
JournalInternational Journal of Biological Macromolecules
StatePublished - 1 Jul 2019
Externally publishedYes


  • Antimicrobial activity
  • Copper complex
  • Nano-cellulose derivatives


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