Mouse model of ulcerative colitis using trinitrobenzene sulfonic acid

Irfan A. Rather, Vivek K. Bajpai, Nam Gyeong-Jun

Research output: Contribution to journalJournal articlepeer-review

1 Scopus citations

Abstract

Animal model of intestinal inflammation is of paramount significance that aids in discerning the pathologies underlying ulcerative colitis and Crohn’s disease, the two clinical presentations of inflammatory bowel disease. The 2,4,6-trinitrobenzene sulfonic acid (TNBS) colitis model represents one such intestinal inflammation-prototype that is generated in susceptible strains of mice through intra-rectal instillation of compound TNBS. In this paper, we demonstrate the experimental induction of TNBSmediated colitis in a susceptible strain of ICR mice. This can be done by the following steps: a) acclimation, b) induction and c) observation. TNBS-mouse model provides the information in shortest possible time and simultaneously represents a cost effective and highly reproducible model method of studying the pathogenesis of inflammatory bowel disease.

Original languageEnglish
Article numberA17
Pages (from-to)860-863
Number of pages4
JournalBangladesh Journal of Pharmacology
Volume10
Issue number4
DOIs
StatePublished - 2015
Externally publishedYes

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