Evaluation of the diuretic effect of conyza dioscorides and alhagi maurorum

Attia H. Atta, Soad M. Nasr, Samar M. Mouneir, Naser Al-Wabel, Soha S. Essawy

Research output: Contribution to journalJournal articlepeer-review

16 Scopus citations

Abstract

The present study aimed to evaluate the diuretic effects of methanol extracts of Conyza dioscorides and Alhagi maurorum in a single or repeated (1 × 5 days) oral dose of 500 or 1000 mg kg-1 and compared to furosemide 20 mg kg-1, orally administered in albino rats. Oral administration of Conyza dioscorides significantly (P < 0.05) decreased serum and urine concentration of Na+, K+ and Cl- concentration when was given in single or repeated doses. The small and large doses increased the sodium and potassium excretion rate (FENa and FEK). Alhagi maurorum in a single oral dose of 500 mg kg-1 significantly (P < 0.05) increased urine concentrations of Na+, K+ and Cl- Repeated oral administration of Alhagi maurorum in doses of 500 or 1000 mgkg-1 significantly (P < 0.05) increased urine volume, FENa and FEK rate. It could be concluded that methanol extracts of Alhagi maurorum have a significant diuretic effect while the extract of Conyza dioscoridis requires further investigation.

Original languageEnglish
Pages (from-to)162-165
Number of pages4
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume2
Issue numberSUPPL. 3
StatePublished - Jul 2010

Keywords

  • Alhagi maurorum
  • Conyza dioscorides
  • Diuretics
  • Medicinal plants

Fingerprint

Dive into the research topics of 'Evaluation of the diuretic effect of conyza dioscorides and alhagi maurorum'. Together they form a unique fingerprint.

Cite this