Enhancement of solublization of ibuprofen using sucrose laurate

Mohamed Saeed, Mohamed Salama

Research output: Contribution to journalJournal articlepeer-review

Abstract

The objective of this paper was to investigate solubility of a poorly-soluble drug (ibuprofen) using sucrose monolaurate. Sucrose laurate was used in this research in different concentrations ranging from 2 to 20% to solubilize ibuprofen. Ibuprofen was analyzed using UV-Visible Spectrophotometer at wave length of 222 nm. The results showed that sucrose laurate in the concentration of 20% gave the best solubility of ibuprofen up to 45 mg/ml. Also the low critical micelle concentration of sucrose laurate favors the solubility of this poorly soluble drug. As a conclusion, this research sucrose laurate can be successfully used for enhancing solubility and hence, the bioavailability of ibuprofen for pediatric administration.

Original languageEnglish
Pages (from-to)604-606
Number of pages3
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume6
Issue number1
StatePublished - 2014
Externally publishedYes

Keywords

  • Ibuprofen
  • Micellar solublization
  • Pharmaceutical applications
  • Solubilization
  • Sucrose laurate

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