Cysteine-mediated excitotoxic neuronal death is an apoptosis-necrosis continuum

Safaa Qusti, Richard B. Parsons, Rosemary H. Waring, David B. Ramsden

Research output: Contribution to journalJournal articlepeer-review

1 Scopus citations

Abstract

To explore the mechanism whereby cysteine induces cell death this study was undertaken using a human medulloblastoma cell-line as the model system. Low levels of cysteine induced several well described phenomena associated with apoptosis, phospatidyl serine exposure, mitochondrial membrane disruption, cleavage of DNA into 50 Kb fragments and induction of caspase 3, whereas higher concentrations tended to cause necrosis. We have speculated on the role of cysteine in excitotoxicity, which occurs clinically following cerebral ischemia.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalJournal of Applied Animal Research
Volume32
Issue number1
DOIs
StatePublished - 2007
Externally publishedYes

Keywords

  • Apoptosis
  • Caspase-3
  • Cysteine
  • Cytotoxicity
  • Mitochondria
  • Necrosis
  • Neurone
  • Phosphatidylserine

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