Copper-catalyzed hydroamination of alkynes with aliphatic amines: Regioselective access to (1 E,3 E)-1,4-disubstituted-1,3-dienes

Janet Bahri, Bassem Jamoussi, Arie Van Der Lee, Marc Taillefer, Florian Monnier

Research output: Contribution to journalJournal articlepeer-review

22 Scopus citations

Abstract

Copper-catalyzed hydroamination of aromatic or heteroaromatic alkynes with cyclic secondary aliphatic amines undergoes generation of an enamine-type intermediate. The latter is transformed in situ via a coupling reaction with a second molecule of alkyne to afford regioselectively (1E,3E)-1,4-disubstituted-1,3-dienes with the formation of C-N, C-C, and C-H bonds.

Original languageEnglish
Pages (from-to)1224-1227
Number of pages4
JournalOrganic Letters
Volume17
Issue number5
DOIs
StatePublished - 6 Mar 2015
Externally publishedYes

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