Comparative X-Ray and conformational analysis of a new crystal of 13α,21-dihydroeurycomanone with eurycomanone from eurycoma longifolia and their anti-estrogenic activity using the uterotrophic assay

Chin Hoe Teh, Mahfoudh Abdulghani, Hiroshi Morita, Motoo Shiro, Abas Hj Hussin, Kit Lam Chan

Research output: Contribution to journalJournal articlepeer-review

19 Scopus citations

Abstract

13,21-Dihydroeurycomanone (1), a known quassinoid of Eurycoma longifolia Jack was recrystallized from chloroform into a novel crystal structure in space group P21. Its Xray data were compared with those of eurycomanone (2). Following intraperioneal injections at similar doses of 2.44 μmol/kg/day for 3 consecutive days, 2 displayed comparable potency with tamoxifen but was more potent than 1 in the anti-estrogenic effect against 17-ethynylestradiol (EE)-induced uterotrophy of immature rats.

Original languageEnglish
Pages (from-to)128-132
Number of pages5
JournalPlanta Medica
Volume77
Issue number2
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • 13 ,21dihydroeurycomanone
  • antiuterotrophic activity
  • conformational analysis
  • Eurycoma longifolia
  • eurycomanone
  • Simaroubaceae
  • Xray

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