Chicory (Cichorium intybus L.) extract ameliorates hydroxyapatite nanoparticles induced kidney damage in rats

Thanaa A. El-Masry, Najla Altwaijry, Badriyah Shadid Alotaibi, Ehab Tousson, Amany M. Alboghdadly, Asmaa Saleh

Research output: Contribution to journalJournal articlepeer-review

5 Scopus citations

Abstract

Hydroxyapatite nanoparticles (HAP NPs) are a calcium phosphate, basically and artificially like the mineral period of human bone and teeth. Current study were performed to study the therapeutic effects of chicory extract towards the injection of hydroxyapatite nanoparticles (HAP NPs) in rat induced kidney damage by decreasing kidney functions, electrolytes, cytokines and apoptosis. An aggregate of 40 Wistar male rats were divided into 4 equal groups [control, chicory, HAP NPs, treated HAP NPs with chicory (HAP NPs+chicory)]. Rat treated with HAP NPs exhibit increased serum creatinine, urea, cystatin C, potassium ions, chloride ions, kidney injury, Bax, PCNA and TNFα expression. In contrast; decline in serum sodium and calcium ions. Post treatments of HAP NPs with chicory extract (HAP NPs+chicory) improved the kidney structure and functions. We can conclude that; chicory extract may offer advantages against the dangerous nature of hydroxyapatite nanoparticles (HAP NPs).

Original languageEnglish
Pages (from-to)1251-1260
Number of pages10
JournalPakistan Journal of Pharmaceutical Sciences
Volume33
Issue number3
DOIs
StatePublished - May 2020

Keywords

  • Bax
  • Chicory extract
  • Hydroxyapatite nanoparticles (HAP NPs)
  • Kidney
  • PCNA
  • TNFα expressions

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