Bisphenol A levels among workers in plastic processing industry and their relations to thyroid hormones

Fateheya M. Metwally, Adel Hasheesh, Mohamad Zayed, Safaa Abd Fattah El Sharkawy, Fatma Al Zahraa Mohamed Abd Fattah, Manal Soliman Mazhar

Research output: Contribution to journalJournal articlepeer-review

2 Scopus citations


Bisphenol A (BPA) is widely used in the plastic processing industry. A cross-sectional study was conducted to measure BPA levels in the serum of workers as a biomarker of occupational exposure, investigate the thyroid hormone profile among BPA exposed workers, and identify the relationship between occupational exposure to BPA and thyroid hormones during. Our data indicate that the studied workers had higher BPA level than that reported for the Egyptian general population, with a median serum level of 15.6 ng/ml and ranged from 1.6 to 62.9 ng/ml while the interquartile range was 16.3 ng/ml, the highest concentration was among the workers of recycling followed by squeegees and PVC departments. As regards thyroid hormones, almost one-third of the studied workers had abnormal thyroid-stimulating hormone (TSH) levels and 12.2% had abnormal T4 levels. According to TSH and T4 levels, 64.4% of the studied workers had normal thyroid function and 35.6% were suffering from subclinical hypothyroidism. No significant correlation between BPA levels and subclinical hypothyroidism was statistically reported. However, our data reported a significant positive correlation between thyroid hormone T3 and serum BPA concentrations. As agonist or antagonist, BPA could bind to the thyroid hormone receptors indicating that remarkable endocrine disruption.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalJournal of Applied Pharmaceutical Science
Issue number11
StatePublished - 2019


  • Bisphenol a
  • Occupational exposure
  • Serum BPA
  • Thyroid hormones


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