Bacteriological and toxicological qualities of dialysis water and associated pyrogenic reactions involved in haemodialysis patients

Samy A. Selim, Sahar M. El Alfy, Atef M. Diab, Sabah Mohamed, H. Abdel Aziz, Mona S. Ewada

Research output: Contribution to journalJournal articlepeer-review

Abstract

The present work surveyed Haemodialysis (HD) units, in order to assess the bacteriological and toxicological qualities of dialysis water and dialysate. Also determine experimentally to how extent the bacterial activities are involved in immune depression for the patients. The most commonly isolated Gram-negative bacteria from treated water were Aeromonas spp. (22.2%). Endotoxin concentrations ranged between 3-113 (EU/mL) for water and dialysate respectively. The haematological analysis had non significant except haemoglobin level had a significant values (p = 0.02). The clinical data showed comparable difference than control patients. Missing, out of work, bypassed and even erroneously arranged treatment facilities are some of the reasons responsible for the detected high levels of bacterial and endotoxin in final product water. The presence and growth of bacteria in water and dialysate should be controlled and the endotoxin testing must be a part of the regular quality control regime, to minimize the risk of adverse reactions in HD patients.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalBiosciences Biotechnology Research Asia
Volume9
Issue number1
DOIs
StatePublished - Jun 2012

Keywords

  • Bacteria
  • Determine experimentally
  • Endotoxins
  • Haemodialysis (HD)
  • Haemodialysis patients
  • Immune depression
  • Limulus Amebocyte Lysate (LAL)

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