Antimicrobial activities of some newly synthesized substituted benzosuberone and its related derivatives

Osama I.Abd El-Salam, Ali S. Alsayed, Korany A. Ali, Ahmed A.Abd Elwahab, Abd El Galil E. Amr, Ghada E.A. Awad

Research output: Contribution to journalJournal articlepeer-review

2 Scopus citations

Abstract

A series of substituted benzosuberone scaffold fused with pyrazole, isoxazole, pyrimidine and triazole moieties were synthesized and evaluated as antimicrobial agents. Some reactions were performed under microwave irradiation, resulted in short time reactions and surprisingly high yields. Some of the obtained products showed remarkable antimicrobial activities and the most active products 7b, 9, 13 and 14 were further tested to evaluate their Minimum Inhibitory Concentration (MIC) value at 125 μg/mL. The structures of new compounds were proved by their elemental analyses and spectral data.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalBiomedical Research (India)
Volume28
Issue number1
StatePublished - 2017
Externally publishedYes

Keywords

  • Antimicrobial activity
  • Pyrazole
  • Pyrimidine
  • Substituted benzosuberone
  • Triazole

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