An efficient synthesis of highly functionalized novel chromeno[4,3-b] pyrroles and indolizino[6,7-b]indoles as potent antimicrobial and antioxidant agents

Natarajan Arumugam, Raghavachary Raghunathan, Abdulrahman I. Almansour, Usama Karama

Research output: Contribution to journalJournal articlepeer-review

48 Scopus citations

Abstract

A facile and efficient synthesis of novel chromeno[4,3-b]pyrroles has been accomplished by intramolecular 1,3-dipolar cycloaddition which on subsequent Pictet-Spengler cyclisation in presence of p-toluenesulfonic acid yielded indolizino[6,7-b]indoles. The synthesized chromenopyrroles and indolizinoindoles were evaluated for their antimicrobial and antioxidant activities. Compounds 7b, 7e, 7a and 7d exhibited respectively, good antibacterial and antifungal activities against tested pathogens when compared to reference control.

Original languageEnglish
Pages (from-to)1375-1379
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number3
DOIs
StatePublished - 1 Feb 2012
Externally publishedYes

Keywords

  • 1,3-DC reaction
  • Antimicrobial activity
  • Azomethine ylide
  • Chromenopyrroles
  • Indolizinoindoles
  • Pictet-Spengler cyclization

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