Absolute configuration of chlorojanerin, a chlorine-containing guaianolide from Centaurea scoparia

Günter Mattern, Edgar Weckert, Diaa Youssef, August W. Frahm

Research output: Contribution to journalJournal articlepeer-review

6 Scopus citations

Abstract

The title guaianolide, chlorojanerin [(1R,3S,4R,5S,6S,-7R,8S)-4-chloromethyl-3,4-dihydroxy-8-(4-hydroxymethacryloyl)- 1H,5H,6H,7H-guaia-10 (14),11(13)-dien-6,12-olide, C19H23ClO7], was obtained from the ethanol extracts of the air-dried aerial flowering parts of the Egyptian plant Centaurea scoparia Sieb. Its absolute configuration has been elucidated by X-ray analysis, which confirms the structure as a chlorine-containing guaianolide with the 4-hydroxymethacryloyl function at the C8 position, as previously proposed on the basis of 1H NMR and CD spectral evidence.

Original languageEnglish
Pages (from-to)1791-1793
Number of pages3
JournalActa Crystallographica Section C: Crystal Structure Communications
Volume52
Issue number7
DOIs
StatePublished - 15 Jul 1996
Externally publishedYes

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